Instructions apply to Outlook 365 and Outlook 2019-2020.
Or, typerunin the Windows Search box and pressEnter.
Outlook should now start in safe mode.

Right-click or tap and hold a blank area on the desktop.
pop in the full path to Outlook.exe, pop in/safeat the end of the path, then selectNext.
Enter a descriptive name for the shortcut, for example,Outlook Safe Mode.

SelectFinishto make the shortcut to Outlook in safe mode and exit that window.
To disable safe mode in Outlook, double-click or double-tap the regular Outlook shortcut you always use.
Safe mode isn’t enabled unless you use one of the methods described on this page.

The path of the file depends on the version of Outlook and whether its the32-bit or 64-bitedition.
If you don’t know what to key in in Command Prompt, see the next section below.
Outlook.exe Location
There are a couple of ways to find where Outlook.exe is stored.

The easiest is to copy the command as you see it below and paste it into Command Prompt.
you better know which version of Outlook you have for this to work.
Go to Command Prompt, right-tap the black screen, and choosePaste.
PressEnterto execute the command.
you could do that with the built-in search tool in Windows ordownload and use a third-party program like Everything.
Do not include any of the bold text or leading spaces when you copy these commands.
Copy and paste from the first double-quotes (including the quotes) all the way to/safe.
Opening Outlook in safe mode doesn’t involve usingWindows Safe Mode; the two aren’t the same.
FAQ
To turn off Safe Mode, press theWindows key+R.
In theOpenfield, entermsconfigand then selectOK.
Select theBoottab and underBoot options, clear theSafe bootcheckbox.
For Hotmail or Outlook.com email, go to theOutlook websiteand selectSign in.
Enter youremail addressand selectNext.
Enter yourpasswordand selectSign in.